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Additionallyfluid retention and edema have been observed in some patients treated with NSAIDsUse of celecoxib may blunt the CV effects of several therapeutic agents used to treat these medical conditionse.gdiureticsACE inhibitorsor angiotensin receptor blockersARBssee DRUG INTERACTIONS

The mechanism of action of CELEBREX is believed to be due to inhibition of prostaglandin synthesisprimarily via inhibition of cyclooxygenase-2COX-2

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to three years duration have shown an increased risk of serious cardiovascularCVthrombotic eventsincluding myocardial infarctionMIand strokewhich can be fatalBased on available datait is unclear that the risk for CV thrombotic events is similar for all NSAIDsThe relative increase in serious CV thrombotic events over baseline conferred by NSAID use appears to be similar in those with and without known CV disease or risk factors for CV diseaseHoweverpatients with known CV disease or risk factors had a higher absolute incidence of excess serious CV thrombotic eventsdue to their increased baseline rateSome observational studies found that this increased risk of serious CV thrombotic events began as early as the first weeks of treatmentThe increase in CV thrombotic risk has been observed most consistently at higher doses.

Get emergency medical help if you have signs of an allergic reaction to Celebrexsneezingrunny or stuffy nosewheezing or trouble breathinghivesswelling of your facelipstongueor throat.

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